Prostaglandins and prostaglandin receptor antago - nism in migraine

15-Deoxy-Δ12,14-Prostaglandin J2 Protects PC12 cells from LPS-Induced Cell Death Through Nrf2 pathway in PPAR-γ Dependent Manner

Introduction: The inflammatory response requires a coordinated integration of various signaling pathway including cyclooxygenase (COX). COX catalyzes the formation of prostaglandins from arachidonic acid. Among prostaglandins, 15-Deoxy-D12, 14-prostaglandin J2 (15d-PGJ2), an endogenous ligand of Peroxisome proliferator-activated receptor-gamma (PPAR-γ), has been demonstrated to have anti-inflam...

Current Concepts of Cerebrovascular Disease — Stroke Clinical Applications of Prostaglandins and Their Inhibitors

One appealing reason for implicating prostaglandins in the pathogenesis of migraine headaches is the ability of one or another of these vasoactive substances to produce constriction or relaxation of cerebral blood vessels, events which are associated, respectively, with the aura and headaches of migraine. Prostaglandins may also be implicated because they reportedly potentiate the effects of br...

Increased main urinary metabolite of prostaglandin F2 alpha excretion in childhood migraine.

Relaxant effect of pioglitazone on the guinea-pig isolated trachea through the modulation of endogenous prostaglandins

Thiazolidinediones are commonly used anti-diabetic drugs. Owing to the anti-inflammatory action of TZDs as a result of there action on the PPAR gamma receptor and a proposed action on the prostaglandins, these drugs can be tried in the acute exacerbations of COPD that are also commonly found among diabetic patients. An experimental study of one week was carried out at animal house of Army Medic...

Role of Local Nerves and Prostaglandins in Regulation of Basal Blood Flow and Hypercapnic Vasodilatation of Cerebral Blood Vessels in the Rabbit

The mechanisms underlying cerebral vasodilatation during hypercapnia are not fully understood. To examine the role of nerves and prostaglandins in the regulation of basal blood flow and in hypercapnia-induced vasodilatation in the cerebral blood vessels of rabbit.Cerebral blood flow was measured by laser Doppler flow-meter in 18 NZW rabbits anesthetized with sodium pentobarbital.  Tetrodetoxin ...